Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1

4 Jan 2021

Abstract excerpt

Diabetic kidney disease (DKD) is a major complication of diabetes. Expression of members of the microRNA (miRNA) miR-379 cluster is increased in DKD. miR-379, the most upstream 5'-miRNA in the cluster, functions in endoplasmic reticulum (ER) stress by targeting EDEM3. However, the in vivo functions of miR-379 remain unclear. We created miR-379 knockout (KO) mice using CRISPR-Cas9 nickase and dual guide RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Extracellular vesicles in disease
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33398021
DOI: 10.1038/s42003-020-01516-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1PMID 33398021Read ↗

Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease SusceptibilitySemantic proximity Read ↗

Role of nuclear receptors, lipid metabolism, and mitochondrial function in the pathogenesis of diabetic kidney diseaseSemantic proximity Read ↗

Important regulatory role of mitophagy in diabetic microvascular complicationsSemantic proximity Read ↗

The Loss of Mitochondrial Quality Control in Diabetic Kidney DiseaseSemantic proximity Read ↗

Mitophagy Regulates Kidney DiseasesSemantic proximity Read ↗

TFAM and Mitochondrial Protection in Diabetic Kidney DiseaseSemantic proximity Read ↗

The role of mitophagy in the development of chronic kidney diseaseSemantic proximity Read ↗

Inhibition of the lncRNA 585189 prevents podocyte injury and mitochondria dysfunction by promoting hnRNP A1 and SIRT1 in diabetic nephropathySemantic proximity Read ↗

Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathySemantic proximity Read ↗

<i>Txn1</i> mutation is a monogenic cause of chronic kidney disease associated with mitochondrial dysfunction in ratsSemantic proximity Read ↗

NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney DiseaseSemantic proximity Read ↗

Deletion of <i>Nudt19</i> Increases Albuminuria in Mice Fed a High Fat DietSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.