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Article

Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis

17 Mar 2025

Abstract excerpt

BACKGROUND: Dyslipidemia or hypercholesterolemia are among the main risk factors for cardiovascular diseases. Unraveling the molecular basis of lipid or cholesterol homeostasis would help to identify novel drug targets and develop effective therapeutics. RESULTS: Here, we adopt a systematic approach to catalog the genes underlying lipid and cholesterol homeostasis by combinatorial use of high-throughput CRISPR...

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PMID: 40098013
DOI: 10.1186/s13059-025-03531-8

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