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Article

MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma

18 Apr 2022

Abstract excerpt

Nuclear transcription factor Mesenchyme Homeobox 2 (MEOX2) is a homeobox gene that is originally discovered to suppress the growth of vascular smooth muscle and endothelial cells. However, whether or not it is connected to cancer is yet unknown. Here, we report that MEOX2 functions as a tumor-initiating element in glioma. Bioinformatic analyses of public databases and investigation of MEOX2 expression in patients...

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PMID: 35436995
DOI: 10.1038/s41419-022-04845-2

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