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E2F7−EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progression

20 Aug 2020

Abstract excerpt

BACKGROUND: E2F transcription factors are considered to be important drivers of tumour growth. E2F7 is an atypical E2F factor, and its role in glioblastoma remains undefined. METHODS: E2F7 expression was examined in patients by IHC and qRT-PCR. The overall survival probability was determined by statistical analyses. MTT assay, colony formation, cell-cycle assay, cell metastasis and the in vivo model were employed...

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PMID: 32814835
DOI: 10.1038/s41416-020-01032-y

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