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Single-Cell Spatial Analysis Identifies Regulators of Brain Tumor–Initiating Cells

17 Apr 2023

Abstract excerpt

Glioblastomas (GBM) are aggressive brain tumors with extensive intratumoral heterogeneity that contributes to treatment resistance. Spatial characterization of GBMs could provide insights into the role of the brain tumor microenvironment in regulating intratumoral heterogeneity. Here, we performed spatial transcriptomic and single-cell analyses of the mouse and human GBM microenvironment to dissect the impact of...

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PMID: 37067922
DOI: 10.1158/0008-5472.can-22-3004

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