Article
CAMK2D causes heart failure in mice with RBM20 cardiomyopathy.
Nature cardiovascular research - 1 May 2026
van den Hoogenhof Maarten M G, Duran Javier, Britto-Borges Thiago, Sequeira Vasco, Kemmling Elena, Konrad Laura, Schreiter Friederike, Lennermann David C, Hartmann Joshua, Schraft Laura, Kornienko Julia, Bock Theresa, Krüger Marcus, Maack Christoph, Dieterich Christoph, Steinmetz Lars M, Dewenter Matthias, Backs Johannes
Abstract excerpt
Although heart disease arises from different etiologies, treatment remains largely one-size-fits-all, leaving many patients without optimal benefit, which highlights the need for cause-directed therapies. Pathogenic variants in RBM20, a cardiac splicing factor, lead to an aggressive form of dilated cardiomyopathy with high risk of ventricular arrhythmias. We hypothesized that the splicing target...
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