Article

Read mismapping from segmental duplications drives spurious <i>trans</i> associations

2025-10-09

Abstract excerpt

Heritable variation in gene regulation shapes both disease risk and evolution. Trans -acting quantitative trait loci ( trans -QTLs) are the primary source of this variation within species, but they remain difficult to identify correctly due to false positives stemming from RNA and DNA read mismapping. Here, we identify four categories of RNA and DNA mismapping due to segmental duplications that lead to false-pos...

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Literature Corpus work: 542a20c1-6772-5d9f-98b5-76b3c1d2e512
DOI: 10.1101/2025.10.08.681258

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