Article

Diverse molecular mechanisms contribute to differential expression of human duplicated genes

2020-11-27

Abstract excerpt

<h4>ABSTRACT</h4> Emerging evidence links genes within human-specific segmental duplications (HSDs) to traits and diseases unique to our species. Strikingly, despite being nearly identical by sequence (>98.5%), paralogous HSD genes are differentially expressed across human cell and tissue types, though the underlying mechanisms have not been examined. We compared cross-tissue mRNA levels of 75 HSD genes from 30 f...

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Literature Corpus work: 14073ff7-afc4-5de4-8b86-8473296a882d
DOI: 10.1101/2020.11.27.401752

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