Article

2’, 3’, 4’-Trihydroxychalcone Changes Estrogen Receptor Α Regulation of Genes and Breast Cancer Cell Proliferation by a Reprogramming Mechanism

2021-09-27

Abstract excerpt

<title>Abstract</title> <p>BackgroundMenopausal hormone therapy (MHT) is recommended for only five years to treat vasomotor symptoms and vulvovaginal atrophy because of safety issues with long-term treatment. We examined the ability of 2’, 3’, 4’-trihydroxychalcone (2’, 3’, 4’-THC) to modulate ERα-mediated responses on gene regulation and cell proliferation to identify drugs that can potentially overcome the adve...

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Literature Corpus work: 5429412c-4aaa-579e-9fee-8abe71a82282
DOI: 10.21203/rs.3.rs-927121/v1

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