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Article

Effects of tobacco smoke condensate on estrogen receptor-alpha gene expression and activity.

Endocrinology - 1 Oct 2007

Martin Mary Beth, Reiter Ronald, Johnson Michael, Shah Mansi S, Iann Mary C, Singh Baljit, Richards Julie Kate, Wang Antai, Stoica Adriana

Abstract excerpt

Metallo-estrogens are a new class of potent environmental estrogens. This study investigates whether tobacco smoke condensate (TSC), which contains metals and metalloids, elicits estrogen-like effects at environmentally relevant doses. Treatment of human breast cancer cells, MCF-7, with 40 microg/ml TSC resulted in a 2.5-fold stimulation of cell growth. TSC decreased the concentration of estrogen receptor...

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Identifiers

PMID: 17640996
DOI: 10.1210/en.2007-0208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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