Article

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males

2020-11-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> COVID-19 clinical presentation ranges from asymptomatic to fatal outcome. This variability is due in part to host genome specific mutations. Recently, two families in which COVID-19 segregates like an X-linked recessive monogenic disorder environmentally conditioned by SARS-CoV-2 have been reported leading to identification of loss-of-function variants in TLR7 . <h4>Objective<...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 541acd05-3355-502b-b45f-ad0faa163bb7
DOI: 10.1101/2020.11.19.20234237

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in malesDOI 10.1101/2020.11.19.20234237Read

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study.Semantic proximity Read

Genetic screening for <i>TLR7</i> variants in young and previously healthy men with severe COVID-19: a case seriesSemantic proximity Read

Stratified analyses refine association between TLR7 rare variants and severe COVID-19.Semantic proximity Read

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19Semantic proximity Read

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.Semantic proximity Read

Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsSemantic proximity Read

From Rare to Common: Genetic Insights into TLR7 Variants in a Multicentric Spanish Study on COVID-19 Severity.Semantic proximity Read

Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patientsSemantic proximity Read

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics InitiativeSemantic proximity Read

Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON).Semantic proximity Read

ACE2, TMPRSS2, and TLR8 single-nucleotide polymorphisms are associated with a high risk of severe COVID-19 disease and deathSemantic proximity Read

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative.Semantic proximity Read