Article

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative

2022-03-30

Abstract excerpt

Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare variants may provide additional insights into disease susceptibility an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6733b009-8585-5a79-a990-2eb8495f55db
DOI: 10.1101/2022.03.28.22273040

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics InitiativeDOI 10.1101/2022.03.28.22273040Read

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative.Semantic proximity Read

Systematic assessment of COVID-19 host genetics using whole genome sequencing data.Semantic proximity Read

Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON).Semantic proximity Read

Stratified analyses refine association between TLR7 rare variants and severe COVID-19.Semantic proximity Read

Host genetic factors determining COVID-19 susceptibility and severity.Semantic proximity Read

Host genetic basis of COVID-19: from methodologies to genesSemantic proximity Read

A second update on mapping the human genetic architecture of COVID-19Semantic proximity Read

Genetic screening for <i>TLR7</i> variants in young and previously healthy men with severe COVID-19: a case seriesSemantic proximity Read

A catalog of associations between rare coding variants and COVID-19 outcomesSemantic proximity Read

Initial Whole Genome Sequencing and Analysis of the Host Genetic Contribution to COVID-19 Severity and SusceptibilitySemantic proximity Read

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severitySemantic proximity Read