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Article

From Rare to Common: Genetic Insights into TLR7 Variants in a Multicentric Spanish Study on COVID-19 Severity.

Journal of clinical immunology - 27 May 2025

Antolí Arnau, Vargas-Parra Gardenia, Sierra-Fortuny Angels, Gomez-Vazquez Jose Luis, Rofes Paula, Munté Elisabet, Viana-Errasti Julen, Marín-Montes Raúl, López-Doriga Adriana, Feliubadaló Lidia, Del Valle Jesús, Pérez-González Alexandre, Poveda Eva, Solanich Xavier, Lázaro Conxi

Abstract excerpt

TLR7, which encodes a key receptor for single-stranded RNA (ssRNA) virus of the innate immune system, was recently associated with X-linked immunodeficiency and COVID-19 susceptibility. This study investigates the association between TLR7 variants and susceptibility to severe COVID-19 in a multicentric Spanish cohort. The TLR7 gene was sequenced in a cohort of 365 COVID-19 patients, stratified into two groups:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40423910
DOI: 10.1007/s10875-025-01892-0
PMCID: PMC12116960

Genes

TLR7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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