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Article

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

23 Jul 2021

Abstract excerpt

Introduction Loss-of-function TLR7 variants have been recently reported in a small number of males to underlie strong predisposition to severe COVID-19. We aimed to determine the presence of these rare variants in young men with severe COVID-19. Methods We prospectively studied males between 18 and 50 years-old without predisposing comorbidities that required at least high-flow nasal oxygen to treat COVID-19. The...

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PMID: 34367187
DOI: 10.3389/fimmu.2021.719115

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