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Single-cell transcriptomics elucidates <i>in vitro</i> reprogramming of human intestinal epithelium cultured in a physiodynamic gut-on-a-chip

2021-09-03

Abstract excerpt

The microphysiological human gut-on-a-chip has demonstrated in vivo -relevant cellular fidelity of intestinal epithelium compared to its cultures in a static condition 1, 2 . Microfluidic control of morphogen gradients and mechanical cues robustly induced morphological histogenesis with villi-like three-dimensional (3D) microarchitecture, lineage-associated cytodifferentiation, and physiological functions of a h...

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Literature Corpus work
5406095e-23f0-5c24-a4d9-de8d9b01588d
DOI
10.1101/2021.09.01.458444
Open publication

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Single-cell transcriptomics elucidates <i>in vitro</i> reprogramming of human intestinal epithelium cultured in a physiodynamic gut-on-a-chipDOI 10.1101/2021.09.01.458444
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