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The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

2019-09-06

Abstract excerpt

Antibiotics are widely used in the treatment of bacterial infections. Although known for their microbicidal activity, antibiotics may also interfere with the host’s immune system. Here we analyzed the effects of bedaquiline (BDQ), an inhibitor of the mycobacterial ATP synthase, on human macrophages. Genome-wide gene expression analysis revealed that BDQ reprogramed macrophages into potent bactericidal phagocytes....

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Literature Corpus work
54056ace-df32-5260-ba87-3f485d0fc5f2
DOI
10.1101/758318
Open publication

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