Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets.

Scientific reports - 2 Mar 2018

Trofimov Valentin, Kicka Sébastien, Mucaria Sabrina, Hanna Nabil, Ramon-Olayo Fernando, Del Peral Laura Vela-Gonzalez, Lelièvre Joël, Ballell Lluís, Scapozza Leonardo, Besra Gurdyal S, Cox Jonathan A G, Soldati Thierry

Abstract excerpt

Tuberculosis remains a serious threat to human health world-wide, and improved efficiency of medical treatment requires a better understanding of the pathogenesis and the discovery of new drugs. In the present study, we performed a whole-cell based screen in order to complete the characterization of 168 compounds from the GlaxoSmithKline TB-set. We have established and utilized novel previously unexplored...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dictyostelium

Share to Drug Discovery

Share to Drug Resistance, Bacterial

Share to Microbial Sensitivity Tests

Share to Microglia

Source

Open in PubMed Open full text

Identifiers

PMID: 29500372
DOI: 10.1038/s41598-018-22228-6
PMCID: PMC5834492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets.PMID 29500372Read ↗

Identification of novel anti-bacterial compounds from a chemically highly diverse pathways-based library using phenotypic screens in amoebae host modelsSemantic proximity Read ↗

Dictyosteliumdiscoideum–Mycobacterium marinum infection model: a powerful high-throughput screening platform for anti-infective compoundsSemantic proximity Read ↗

Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screeningSemantic proximity Read ↗

Multidrug-resistant tuberculosis: a comprehensive review of pathogenesis, drug resistance, current treatment and future prospects.Semantic proximity Read ↗

Utilisation of the Prestwick Chemical Library <sup>®</sup> to identify drugs that inhibit the growth of MycobacteriaSemantic proximity Read ↗

Target Identification in Anti-Tuberculosis Drug DiscoverySemantic proximity Read ↗

Exploring host–pathogen interactions in the Dictyostelium discoideum–Mycobacterium marinum infection model of tuberculosisSemantic proximity Read ↗

Azetidines kill <i>Mycobacterium tuberculosis</i> without detectable resistance by blocking mycolate assemblySemantic proximity Read ↗

The Repurposing of FDA-Approved Drugs as FtsZ Inhibitors against Mycobacterium tuberculosis: An In Silico and In Vitro StudySemantic proximity Read ↗

Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host modelSemantic proximity Read ↗

Host-Pathogen Interaction as a Novel Target for Host-Directed Therapies in TuberculosisSemantic proximity Read ↗

Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.