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Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failure

3 Jan 2023

Abstract excerpt

Total fertilization failure (TFF), which refers to fertilization failure in all mature oocytes, accounting for 5%-10% of in vitro fertilization (IVF) cycles and 1%-3% of intracytoplasmic sperm injection (ICSI) cycles in human. In this study, we recruited three unrelated primary infertile men with repeated cycles of TFF and performed whole-exome sequencing to identify the potential pathogenic variants. We...

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Identifiers

PMID: 36593593
DOI: 10.1111/cge.14293

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