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SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia

4 Sept 2012

Abstract excerpt

SPACA1 is a membrane protein that localizes in the equatorial segment of spermatozoa in mammals and is reported to function in sperm-egg fusion. We produced a Spaca1 gene-disrupted mouse line and found that the male mice were infertile. The cause of this sterility was abnormal shaping of the sperm head reminiscent of globozoospermia in humans. Disruption of Spaca1 led to the disappearance of the nuclear plate, a...

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PMID: 22949614
DOI: 10.1242/dev.081778

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