Article

Inhibition of farnesyltransferase activity diminishes hematopoietic stem cell <i>ex vivo</i> expansion ability

2025-10-31

Abstract excerpt

<h4>ABSTRACT/SUMMARY</h4> The rationale underlying this work is that elucidating the contribution of farnesyltransferase activity to hematopoietic stem cell expansion ex vivo will provide knowledge needed to better support hematopoietic stem cell expansion techniques for clinical applications that rely on this approach, like hematopoietic cell transplants and gene therapy. We discovered that pharmacological inhi...

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Literature Corpus work: 53ea7489-6a83-51b3-ac9a-4420a06975df
DOI: 10.1101/2025.10.30.685582

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