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Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

18 Sept 2014

Abstract excerpt

The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The potent activity of these newly identified compounds,...

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PMID: 25237102
DOI: 10.1126/science.1256337

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