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Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell

17 Dec 2021

Abstract excerpt

Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many diseases. HSCs from umbilical cord blood (UCB) source have many advantages over from bone marrow. However, limited HSC dose in a single CB unit restrict its widespread use. Over the past two decades, ex vivo HSC expansion with small molecules has been an effective approach for obtaining adequate HSCs. Till now, several...

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PMID: 35755294
DOI: 10.1016/j.apsb.2021.12.006

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