Article

Mitofusin agonists improve the long-term repopulating activity of human cord blood HSCs after <i>ex vivo</i> culture

2025-10-27

Abstract excerpt

Umbilical cord blood (CBU) is a valuable source of hematopoietic stem cells (HSCs) due to lower incidence of graft-versus-host disease. However, limited HSC counts restrict use in adults, necessitating improved methods for ex vivo expansion and improved HSC function. Mitofusin 2 (MFN2), a mitochondrial membrane fusion protein, is necessary for preserving HSC function and mitofusin agonists have been characterized...

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Literature Corpus work: 77bd6956-299b-5c9c-82c3-ca7c8f048907
DOI: 10.1101/2025.10.27.684807

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