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Ex vivo expansion and functional activity preservation of adult hematopoietic stem cells by a diarylheptanoid from Curcuma comosa.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Nov 2021

Tanhuad Nopmullee, Thongsa-Ad Umnuaychoke, Sutjarit Nareerat, Yoosabai Ploychompoo, Panvongsa Wittaya, Wongniam Sirapope, Suksamrarn Apichart, Piyachaturawat Pawinee, Anurathapan Usanarat, Borwornpinyo Suparerk, Chairoungdua Arthit, Hongeng Suradej, Bhukhai Kanit

Abstract excerpt

Hematopoietic stem cells (HSCs, CD34+ cells) have shown therapeutic efficacy for transplantation in various hematological disorders. However, a large quantity of HSCs is required for transplantation. Therefore, strategies to increase HSC numbers and preserve HSC functions through ex vivo culture are critically required. Here, we report that expansion medium supplemented with ASPP 049, a diarylheptanoid isolated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34474347
DOI: 10.1016/j.biopha.2021.112102

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