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Article

Escherichia coli cultures maintain stable subpopulation structure during long-term evolution.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 2018

Behringer Megan G, Choi Brian I, Miller Samuel F, Doak Thomas G, Karty Jonathan A, Guo Wanfeng, Lynch Michael

Abstract excerpt

How genetic variation is generated and maintained remains a central question in evolutionary biology. When presented with a complex environment, microbes can take advantage of genetic variation to exploit new niches. Here we present a massively parallel experiment where WT and repair-deficient (∆mutL) Escherichia coli populations have evolved over 3 y in a spatially heterogeneous and nutritionally complex...

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Identifiers

PMID: 29712844
DOI: 10.1073/pnas.1708371115
PMCID: PMC5960275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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