Article

Corticosteroid resistance is predetermined by early immune response dynamics at acute Graft-versus-Host disease onset

2025-01-12

Abstract excerpt

Steroid-resistant acute graft versus host disease (SR-aGVHD) is the leading life-threatening complication following allogeneic hematopoietic stem cell transplantation. Novel therapeutics development is impeded by scares knowledge on biological pathways leading to steroid resistance at time of aGVHD diagnosis. To gain insight into our understanding on circulating immune cell subsets and functions at time of aGVHD,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 53b0b388-869c-5559-ab9b-c4415da3f59c
DOI: 10.1101/2025.01.12.632608

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Corticosteroid resistance is predetermined by early immune response dynamics at acute Graft-versus-Host disease onsetDOI 10.1101/2025.01.12.632608Read

Emerging novel therapies for steroid-refractory acute graft-versus-host disease: recent advances and future directionsSemantic proximity Read

Stress responses, M2 macrophages, and a distinct microbial signature in fatal intestinal acute graft-versus-host diseaseSemantic proximity Read

Single-cell transcriptomics of allo-reactive CD4 <sup>+</sup> T cells over time reveals divergent fates during gut GVHDSemantic proximity Read

Single-cell Landscape Analysis Unravels Molecular Programming of the Human B Cell Compartment in Chronic GVHDSemantic proximity Read

Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHDSemantic proximity Read

Mechanistic insights into B-cell activation and autoreactivity regulation in active SLE and remissionSemantic proximity Read

Prednisone Reprograms the Transcriptional Immune Cell Landscape in CNS Autoimmune DiseaseSemantic proximity Read

Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD can discriminate patients at high risk of steroid refractory acute GVHD.Semantic proximity Read

Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosusSemantic proximity Read

A New Risk Score System for Early Warning Gastrointestinal Graft-Versus-Host Disease Based on the Immune Function of Mucosal-Associated Invariant T CellsSemantic proximity Read

Glucocorticoid-resistant Th17 cells are selectively attenuated by cyclosporine A.Semantic proximity Read

Distinctive Transcriptional and Microbial Signature in Cutaneous Acute Graft-vs-Host-DiseaseSemantic proximity Read