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Stress responses, M2 macrophages, and a distinct microbial signature in fatal intestinal acute graft-versus-host disease

8 Aug 2019

Abstract excerpt

Steroid-refractory intestinal acute graft-versus-host disease (aGVHD) is a frequently fatal condition with little known about mechanisms driving failed steroid responses in gut mucosa. To uncover novel molecular insights in steroid-refractory aGVHD, we compared gene expression profiles of rectosigmoid biopsies from patients at diagnosis of clinical stage 3-4 lower intestinal aGVHD (N=22), to repeat biopsies when...

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PMID: 31393854
DOI: 10.1172/jci.insight.129762

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