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Emerging novel therapies for steroid-refractory acute graft-versus-host disease: recent advances and future directions

26 Aug 2025

Abstract excerpt

Acute graft-versus-host disease (aGVHD) is a significant complication of allogeneic hematopoietic cell transplantation (allo-HCT), characterized by immune-mediated tissue damage from donor immune cells. Standard treatment of aGVHD involves systemic corticosteroids, but many patients do not respond adequately, with 30%-50% of patients being steroid refractory (SR-aGVHD) leading to poor outcomes. This highlights...

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PMID: 40865409
DOI: 10.1016/j.coi.2025.102649

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