Article
Glucocorticoid-resistant Th17 cells are selectively attenuated by cyclosporine A.
Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 2015
Schewitz-Bowers Lauren P, Lait Philippa J P, Copland David A, Chen Ping, Wu Wenting, Dhanda Ashwin D, Vistica Barbara P, Williams Emily L, Liu Baoying, Jawad Shayma, Li Zhiyu, Tucker William, Hirani Sima, Wakabayashi Yoshiyuki, Zhu Jun, Sen Nida, Conway-Campbell Becky L, Gery Igal, Dick Andrew D, Wei Lai, Nussenblatt Robert B, Lee Richard W J
Abstract excerpt
Glucocorticoids remain the cornerstone of treatment for inflammatory conditions, but their utility is limited by a plethora of side effects. One of the key goals of immunotherapy across medical disciplines is to minimize patients' glucocorticoid use. Increasing evidence suggests that variations in the adaptive immune response play a critical role in defining the dose of glucocorticoids required to control an...
Topics
- Animals
- Autoimmunity
- CD4-Positive T-Lymphocytes
- Calcineurin
- Calcineurin Inhibitors
- Cell Nucleus
- Cell Proliferation
- Cyclosporine
- Disease Models, Animal