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Article

Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila.

Nature communications - 14 Nov 2016

Kandul Nikolay P, Zhang Ting, Hay Bruce A, Guo Ming

Abstract excerpt

Mitochondrial DNA (mtDNA) often exists in a state of heteroplasmy, in which mutant mtDNA co-exists in cells with wild-type mtDNA. High frequencies of pathogenic mtDNA result in maternally inherited diseases; maternally and somatically acquired mutations also accumulate over time and contribute to diseases of ageing. Reducing heteroplasmy is therefore a therapeutic goal and in vivo models in post-mitotic tissues...

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Identifiers

PMID: 27841259
DOI: 10.1038/ncomms13100
PMCID: PMC5114534

Genes

PINK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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