Article

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

2020-03-29

Abstract excerpt

Aneuploidy, the loss and gain of whole and part chromosomes, is near-ubiquitous in cancer genomes and likely defines cancer cell biology. However, the temporal evolutionary dynamics that select for aneuploidy remain uncharacterised. Here we perform longitudinal genomic analysis of 755 samples from a total of 167 patients with colorectal-derived neoplastic lesions that represent distinct stages of tumour evolution...

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Literature Corpus work: 5379d9e3-fa93-5dbc-8a3b-3647ef533ad8
DOI: 10.1101/2020.03.26.007138

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