Article

Interplay between polygenic effects and polypharmacy on dementia: An investigation in an elderly Scottish cohort

2024-11-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Polygenic Risk Scores for Alzheimer dementia (AD-PRS), a measure of aggregate AD genetic risk and polypharmacy have been associated with dementia. Here, we test their interaction’s association with future dementia among older adults without baseline neurodegenerative diagnoses. <h4>METHODS</h4> Using Cox proportional hazards and mortality-adjusted competing risk regression m...

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Literature Corpus work: 534f71ab-fe88-5357-abb9-66972a65c332
DOI: 10.1101/2024.11.01.24316584

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