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Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryo

2021-07-08

Abstract excerpt

The human endogenous retrovirus type-H (HERVH) family is expressed in the preimplantation embryo. A subset of these elements are specifically transcribed in pluripotent stem cells where they appear to exert regulatory activities promoting self-renewal and pluripotency. How HERVH elements achieve such transcriptional specificity remains poorly understood. To uncover the sequence features underlying HERVH transcript...

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Literature Corpus work
7ce72cad-9264-5443-bc1b-e8a3e19b2f5b
DOI
10.1101/2021.07.08.451617
Open publication

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Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryoDOI 10.1101/2021.07.08.451617
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