Article

A Comprehensive Annotation of Conserved Protein Domains in Human Endogenous Retroviruses

2025-07-27

Abstract excerpt

Human endogenous retroviruses (HERVs) occupy nearly 8% of the human genome, yet their protein-coding potential remains largely unexplored. HERVs originate from ancestral exogenous retroviruses that infected germline cells and became integrated into the human genome. Like their exogenous counterparts, they typically follow the canonical proviral structure: LTR–gag–pol–env–LTR, where gag, pol, and env encode structu...

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Literature Corpus work: 96b2f44a-76a7-5c9d-9fd8-f5106b39354b
DOI: 10.1101/2025.07.25.666750

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