Article
A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium
2021-06-21
Abstract excerpt
The most successful genetically encoded calcium indicators (GECIs) employ an intensity or intensiometric readout. Despite a large calcium-dependent change in fluorescence intensity, the quantification of calcium concentrations with GECIs is problematic, which is further complicated by the sensitivity of all GECIs to changes in the pH in the biological range. Here, we report on a novel sensing strategy in which a c...
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Identifiers and source
- Literature Corpus work
- 530a70d8-1c5d-5252-b697-ebdbba290c0b
- DOI
- 10.1101/2021.06.21.449214