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Increased serum Neurofilament light chain levels in Parkinson’s Disease patients carrying the p.A53T <i>SNCA</i> mutation: Data from the PPMI study

2025-08-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Serum neurofilament light chain (NfL) levels, a marker of axonal damage, are generally elevated in neurodegenerative conditions, but results in idiopathic Parkinson’s Disease (iPD) have been inconsistent. The p.A53T mutation in the SNCA gene usually leads to a severe, rapidly progressing genetic form of PD. <h4>Objectives</h4> Assessing the possible use of serum NfL as a...

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Literature Corpus work: 52f1f5be-5c76-5abb-80aa-50ea159f83c9
DOI: 10.1101/2025.08.28.25334674

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