Article

Serum UCHL-1, GFAP, and NfL track tyrosine hydroxylase loss in substantia nigra in two Rat Models of Parkinson’s Disease

2026-07-20

Abstract excerpt

<h4>ABSTRACT</h4> In Parkinson’s disease (PD), blood-based (BB) biomarkers ubiquitin c-terminal hydrolase L 1 (UCHL-1), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) correlate with motor or cognitive impairment. However, it is unclear if blood levels of these biomarkers represent changes in nigrostriatal neuron viability or dopamine (DA) signaling. In 6-OHDA and Pink1 knockout (KO) rat mod...

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Literature Corpus work: 0d87f822-6c84-5242-97be-293e5e5de264
DOI: 10.64898/2026.07.14.738586

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