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Neurofilament light chain as a mediator between LRRK2 mutation and dementia in Parkinson’s disease

12 Sept 2023

Abstract excerpt

Elevated neurofilament light chain (NfL) levels have been associated with dementia in idiopathic Parkinson's disease (iPD). To examine the baseline and longitudinal changes in NfL levels in GBA-PD, SNCA-PD, and LRRK2-PD and further investigate the association between these genetic mutations, NfL, and dementia in PD. We analyzed data from the Parkinson's Progression Markers Initiative (PPMI), including 184 healthy...

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PMID: 37699957
DOI: 10.1038/s41531-023-00572-3

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