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Article

Serum neurofilament light chain in LRRK2 related Parkinson's disease: A five years follow-up.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Apr 2023

Nabizadeh Fardin, Mohamadzadeh Omid, Hosseini Helia, Rasouli Kimia, Afyouni Nazgol Esmalian

Abstract excerpt

BACKGROUND: Studies revealed that serum neurofilament light chain (NFL) levels not only increase considerably over time in Parkinson's disease (PD) but also have a significant association with disease progression. However, there is no evidence of the level of serum NFL in PD patients with leucine-rich repeat kinase 2 (LRRK2) mutation (LRRK2-PD) which is the most common mutation that causes familial and sporadic...

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PMID: 36780781
DOI: 10.1016/j.jocn.2023.01.015

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