Article
Increased Serum Neurofilament Light Chain Levels in Parkinson's Disease Patients Carrying the p.A53T SNCA Mutation: Data from the Parkinson's Progression Markers Initiative Study.
Movement disorders : official journal of the Movement Disorder Society - 1 Jun 2026
Papagiannakis Nikolaos, Koros Christos, Simitsi Athina-Maria, Stefanis Leonidas
Abstract excerpt
BACKGROUND: Serum neurofilament light chain (NfL) levels, a marker of axonal damage, are generally elevated in neurodegenerative conditions, but results in idiopathic Parkinson's disease (iPD) have been inconsistent. The p.A53T SNCA mutation usually leads to a severe form of PD. OBJECTIVE: The aim of this work was to assess the possible use of serum NfL as a marker of ongoing neurodegeneration in A53T-PD....
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