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Article

A mutant form of PTEN linked to autism.

Protein science : a publication of the Protein Society - 1 Oct 2010

Redfern Roberta E, Daou Marie-Claire, Li Li, Munson Mary, Gericke Arne, Ross Alonzo H

Abstract excerpt

The tumor suppressor, phosphatase, and tensin homologue deleted on chromosome 10 (PTEN), is a phosphoinositide (PI) phosphatase specific for the 3-position of the inositol ring. PTEN has been implicated in autism for a subset of patients with macrocephaly. Various studies identified patients in this subclass with one normal and one mutated PTEN gene. We characterize the binding, structural properties, activity,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20718038
DOI: 10.1002/pro.483
PMCID: PMC2998728

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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