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Article

Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.

International journal of molecular medicine - 1 Jan 2020

Wang Xiang, Lin Lianjun, Chai Xiaoyu, Wu Yanping, Li Yong, Liu Xinmin

Abstract excerpt

Pulmonary vascular remodeling and fibrosis are the critical pathological characteristics of hypoxic pulmonary hypertension. Our previous study demonstrated that hypoxia is involved in the functional alteration of lung fibroblasts, but the underlying mechanism has yet to be fully elucidated. The aim of the present study was to investigate the effect of mast cells on the proliferation, function and phenotype of...

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Identifiers

PMID: 31746371
DOI: 10.3892/ijmm.2019.4400
PMCID: PMC6889934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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