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Article

The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension.

American journal of respiratory cell and molecular biology - 1 Jul 2023

Hu Cheng-Jun, Laux Aya, Gandjeva Aneta, Wang Liyi, Li Min, Brown R Dale, Riddle Suzette, Kheyfets Vitaly O, Tuder Rubin M, Zhang Hui, Stenmark Kurt R

Abstract excerpt

Hypoxia-inducible factor (HIF) has received much attention as a potential pulmonary hypertension (PH) treatment target because inhibition of HIF reduces the severity of established PH in rodent models. However, the limitations of small-animal models of PH in predicting the therapeutic effects of pharmacologic interventions in humans PH are well known. Therefore, we sought to interrogate the role of HIFs in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36944195
DOI: 10.1165/rcmb.2022-0114OC
PMCID: PMC10324042

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