Article

Tumor microenvironment acidosis favors pancreatic cancer stem cell properties and <i>in vivo</i> metastasis

2024-06-17

Abstract excerpt

The acidic tumor microenvironment favors cancer aggressiveness via incompletely understood pathways. Here, we asked whether acidic environments select for cancer stem cell (CSC) properties. Bulk RNA-seq of Panc-1 human pancreatic cancer cells adapted to extracellular pH 6.5 revealed upregulation of CSC markers including CD44, EpCam, Nestin and aldehyde dehydrogenases, and CSC pathway enrichment. We therefore asses...

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Literature Corpus work: 52c91ee5-9dc8-55c4-998a-8287cd484d81
DOI: 10.1101/2024.06.14.599032

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