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Article

Therapeutic Targeting of Cancer Stem Cells: Integrating and Exploiting the Acidic Niche

19 Mar 2019

Abstract excerpt

Cancer stem cells (CSC) or tumor-initiating cells represent a small subpopulation of cells within the tumor bulk that share features with somatic stem cells, such as self-renewal and pluripotency. From a clinical point of view, CSC are thought to be the main drivers of tumor relapse in patients by supporting treatment resistance and dissemination to distant organs. Both genome instability and...

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PMID: 30941310
DOI: 10.3389/fonc.2019.00159

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