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Tumor microenvironment acidosis favors pancreatic cancer stem cell properties and in vivo metastasis

5 Feb 2025

Abstract excerpt

The acidic tumor microenvironment (TME) favors cancer aggressiveness via incompletely understood pathways. Here, we asked whether adaptation to environmental acidosis (pH 6.5) selects for human pancreatic cancer stem cell (CSC) properties. RNA sequencing (RNA-seq) of acid-adapted (AA) Panc-1 cells revealed CSC pathway enrichment and upregulation of CSC markers. AA Panc-1 cells exhibited classical CSC...

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PMID: 40083719
DOI: 10.1016/j.isci.2025.111956

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