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Article

CpG content in the Zika virus genome affects infection phenotypes in the adult brain and fetal lymph nodes.

Frontiers in immunology - 1 Jan 2022

Udenze Daniel, Trus Ivan, Berube Nathalie, Karniychuk Uladzimir

Abstract excerpt

Increasing the number of CpG dinucleotides in RNA viral genomes, while preserving the original amino acid composition, leads to impaired infection which does not cause disease. Beneficially, impaired infection evokes antiviral host immune responses providing a cutting-edge vaccine approach. For example, we previously showed that CpG-enriched Zika virus variants cause attenuated infection phenotypes and protect...

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Identifiers

PMID: 35983032
DOI: 10.3389/fimmu.2022.943481
PMCID: PMC9379343

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