Article

Evolution and antiviral activity of a human protein of retroviral origin

2020-08-24

Abstract excerpt

Endogenous retroviruses are abundant components of mammalian genomes descended from ancient germline infections. In several mammals, the envelope proteins encoded by these elements protect against exogenous viruses, but this activity has not been documented in human. We report that our genome harbors a large pool of envelope-derived sequences with the potential to restrict retroviral infection. To further test thi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b4fe021-e3f8-57ec-8a2b-46d10fc94251
DOI: 10.1101/2020.08.23.263665

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolution and antiviral activity of a human protein of retroviral originDOI 10.1101/2020.08.23.263665Read

The ancient fusogen EnvP(b)1 is expressed in human tissues and its structure informs the evolution of gammaretrovirus envelope proteinsSemantic proximity Read

'There and back again': revisiting the pathophysiological roles of human endogenous retroviruses in the post-genomic era.Semantic proximity Read

HEMO, an ancestral endogenous retroviral envelope protein shed in the blood of pregnant women and expressed in pluripotent stem cells and tumorsSemantic proximity Read

Human endogenous retroviruses and exogenous viral infectionsSemantic proximity Read

Analysis of 8839 pan-primate retroviral LTR elements with regulatory functions during human embryogenesis reveals their global impacts on evolution of Modern HumansSemantic proximity Read

An immune-suppressing protein in human endogenous retrovirusesSemantic proximity Read

Human Endogenous Retroviruses in Health and Disease: A Symbiotic PerspectiveSemantic proximity Read

The in silico identification and analysis of ancient and recent endogenous retroviruses in mammalian genomesSemantic proximity Read

Classification and characterization of human endogenous retroviruses; mosaic forms are common.Semantic proximity Read

A novel human endogenous retroviral protein inhibits cell-cell fusionSemantic proximity Read

A Comprehensive Annotation of Conserved Protein Domains in Human Endogenous RetrovirusesSemantic proximity Read

Identification of an endogenous retroviral envelope gene with fusogenic activity and placenta-specific expression in the rabbit: a new "syncytin" in a third order of mammalsSemantic proximity Read