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Article

Penetration, Adhesion, and Fusion in Mammalian Sperm-Egg Interaction

21 Jun 2002

Abstract excerpt

Fertilization is the sum of the cellular mechanisms that pass the genome from one generation to the next and initiate development of a new organism. A typical, ovulated mammalian egg is enclosed by two layers: an outer layer of approximately 5000 cumulus cells and an inner, thick extracellular matrix, the zona pellucida. To reach the egg plasma membrane, sperm must penetrate both layers in steps requiring sperm...

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PMID: 12077404
DOI: 10.1126/science.1072029

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