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Defects in RNase H2 Stimulate DNA Break Repair by RNA Reverse Transcribed into cDNA.

MicroRNA (Shariqah, United Arab Emirates) - 1 Jan 2015

Keskin Havva, Storici Francesca

Abstract excerpt

Eukaryotic ribonucleases (RNase) H1 and H2 are endonucleases that cleave RNA in a double- stranded RNA-DNA molecule. RNase H2 can also cleave a single ribonucleotide embedded in DNA duplex. While the activity of RNase H1 and H2 has been extensively characterized in vitro, still much is unclear about the specific targets of these enzymes in vivo. We recently demonstrated that yeast cells can repair a double-strand...

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PMID: 26456534
DOI: 10.2174/2211536604666150820120129

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PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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